Ontology highlight
ABSTRACT:
SUBMITTER: Mrozowska PS
PROVIDER: S-EPMC4862332 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Mrozowska Paulina S PS Fukuda Mitsunori M
The Journal of cell biology 20160502 3
MDCK II cells, a widely used model of polarized epithelia, develop into different structures depending on culture conditions: two-dimensional (2D) monolayers when grown on synthetic supports or three-dimensional (3D) cysts when surrounded by an extracellular matrix. The establishment of epithelial polarity is accompanied by transcytosis of the apical marker podocalyxin from the outer plasma membrane to the newly formed apical domain, but its exact route and regulation remain poorly understood. H ...[more]