Ontology highlight
ABSTRACT:
SUBMITTER: Sato SM
PROVIDER: S-EPMC4862752 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Sato Satoru M SM Woolley Catherine S CS
eLife 20160415
Status epilepticus (SE) is a common neurological emergency for which new treatments are needed. In vitro studies suggest a novel approach to controlling seizures in SE: acute inhibition of estrogen synthesis in the brain. Here, we show in rats that systemic administration of an aromatase (estrogen synthase) inhibitor after seizure onset strongly suppresses both electrographic and behavioral seizures induced by kainic acid (KA). We found that KA-induced SE stimulates synthesis of estradiol (E2) i ...[more]