Dataset Information

Sex differences in the serum level of endogenous ligands for estrogen receptor ? in the elderly population.

ABSTRACT: Animal studies suggest that estrogen receptor ? (ER?)-agonists, but not ER?-agonists, are antidepressants. Several endogenous ligands for ER? have been proposed, including 5?-androstane-3?, 17?-diol (3?Adiol), Androstenediol (?5-diol), and 7?-hydroxydehydroepiandrosterone (7?-OH-DHEA). The aim of this study was to determine the serum and salivary levels of natural ER? ligands in men and women with and without past depressive episodes in the elderly population. DHEA (a precursor of 3?Adiol, ?5-diol, and 7?-OH-DHEA), 17?-estradiol (E2), and cortisol (F) were also measured. Samples were collected from 51 subjects and liquid chromatography tandem mass spectrometry was used for measurement. Comparisons were made between groups based on sex and depression history. E2, 3?Adiol, and ?5-diol levels were significantly lower in women than in men regardless of depression history. There were no significant differences between men and women in DHEA or 7?-OH-DHEA levels. DHEA was significantly lower in women with depression than in women without depression. Reduced DHEA levels may be related to depression vulnerability in women. Further studies are needed to determine the mechanism underlying sex differences in the prevalence of depression and increased risk of depression during menopause. Not only E2 but also two other estrogenic steroids (3?Adiol and ?5-diol) should be involved in these studies.

SUBMITTER: Kobayashi M

PROVIDER: S-EPMC4863166 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature

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Sex differences in the serum level of endogenous ligands for estrogen receptor β in the elderly population.

Kobayashi Miyuki M Sugiyama Nobuhiro N Sasayama Daimei D Sasamoto Hidehiko H Miyashiro Yoshimichi Y Arima Kunimasa K Washizuka Shinsuke S

Scientific reports 20160511

Animal studies suggest that estrogen receptor β (ERβ)-agonists, but not ERα-agonists, are antidepressants. Several endogenous ligands for ERβ have been proposed, including 5α-androstane-3β, 17β-diol (3βAdiol), Androstenediol (Δ5-diol), and 7α-hydroxydehydroepiandrosterone (7α-OH-DHEA). The aim of this study was to determine the serum and salivary levels of natural ERβ ligands in men and women with and without past depressive episodes in the elderly population. DHEA (a precursor of 3βAdiol, Δ5-di ...[more]

PMID: 27165125

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Project description:BackgroundSex is an important factor in the prevalence, incidence, progression, and response to treatment of many medical conditions, including autoimmune and cardiovascular diseases and psychiatric conditions. Identification of molecular differences between typical males and females can provide a valuable basis for exploring conditions differentially affected by sex.Methodology/principal findingsUsing multiplexed immunoassays, we analyzed 174 serum molecules in 9 independent cohorts of typical individuals, comprising 196 males and 196 females. Sex differences in analyte levels were quantified using a meta-analysis approach and put into biological context using k-means to generate clusters of analytes with distinct biological functions. Natural sex differences were established in these analyte groups and these were applied to illustrate sexually dimorphic analyte expression in a cohort of 22 males and 22 females with Asperger syndrome. Reproducible sex differences were found in the levels of 77 analytes in serum of typical controls, and these comprised clusters of molecules enriched with distinct biological functions. Analytes involved in fatty acid oxidation/hormone regulation, immune cell growth and activation, and cell death were found at higher levels in females, and analytes involved in immune cell chemotaxis and other indistinct functions were higher in males. Comparison of these naturally occurring sex differences against a cohort of people with Asperger syndrome indicated that a cluster of analytes that had functions related to fatty acid oxidation/hormone regulation was associated with sex and the occurrence of this condition.Conclusions/significanceSex-specific molecular differences were detected in serum of typical controls and these were reproducible across independent cohorts. This study extends current knowledge of sex differences in biological functions involved in metabolism and immune function. Deviations from typical sex differences were found in a cluster of molecules in Asperger syndrome. These findings illustrate the importance of investigating the influence of sex on medical conditions.

Dataset Information

Sex differences in the serum level of endogenous ligands for estrogen receptor ? in the elderly population.

Publications

Sex differences in the serum level of endogenous ligands for estrogen receptor β in the elderly population.

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