Ontology highlight
ABSTRACT:
SUBMITTER: Barlow PN
PROVIDER: S-EPMC4863441 | biostudies-literature | 2008
REPOSITORIES: biostudies-literature
Barlow Paul N PN Hageman Gregory S GS Lea Susan M SM
Advances in experimental medicine and biology 20080101
Complement Factor H has recently come to the fore with variant forms implicated in a range of serious disease states. This review aims to bring together recent data concerning the structure and biological activity of this molecule to highlight the way in which a molecular understanding of function may open novel therapeutic possibilities. In particular we examine the evidence for and against the hypothesis that sequence variations in factor H may predispose to disease if they perturb its ability ...[more]