Ontology highlight
ABSTRACT:
SUBMITTER: Remedio L
PROVIDER: S-EPMC4863737 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Remédio Leonor L Gribble Katherine D KD Lee Jennifer K JK Kim Natalie N Hallock Peter T PT Delestrée Nicolas N Mentis George Z GZ Froemke Robert C RC Granato Michael M Burden Steven J SJ
Genes & development 20160501 9
Motor axons approach muscles that are prepatterned in the prospective synaptic region. In mice, prepatterning of acetylcholine receptors requires Lrp4, a LDLR family member, and MuSK, a receptor tyrosine kinase. Lrp4 can bind and stimulate MuSK, strongly suggesting that association between Lrp4 and MuSK, independent of additional ligands, initiates prepatterning in mice. In zebrafish, Wnts, which bind the Frizzled (Fz)-like domain in MuSK, are required for prepatterning, suggesting that Wnts may ...[more]