Unknown

Dataset Information

0

Sexual Dimorphic Metabolic Alterations in Hepatitis C Virus-infected Patients: A Community-Based Study in a Hepatitis B/Hepatitis C Virus Hyperendemic Area.


ABSTRACT: The impact of sex on metabolic alterations in individuals with hepatitis B virus (HBV) or hepatitis C virus (HCV) infection remains elusive.A community-based study was performed to assess sex, age, body mass index, the lipid profile, blood pressure, glucose, alanine aminotransferase, HBV surface antigen (HBsAg), and HCV antibody levels, smoking and alcohol drinking habits, and cardiometabolic diseases, including diabetes, hypertension, cardiovascular events, and renal diseases. The HCV-RNA level and genotype were further assessed in HCV antibody-positive subjects, and the hepatitis B e antigen and HBV-DNA levels were further examined in HBsAg-positive subjects.Among the 10,959 adults enrolled, 1949 (17.8%) and 1536 (14.0%) were HBV and HCV-infected, respectively. Univariate and multivariate analyses showed that the lipid profile and hypertension were independently associated with HCV infection (95% confidence intervals of odds ratios [OR 95% CI]: total cholesterol [TC]?=?0.508-0.677; triglycerides?=?0.496-0.728; hypertension?=?0.669-0.937), but not with HBV infection. Consistently, HCV, but not HBV infection, was negatively associated with the TC and triglyceride levels (OR 95% CI for TC: 0.450-0.601; triglycerides: 0.443-0.671). Generalized linear models revealed that HCV infection, sex, and age interactively affected the lipid profile (OR 95% CI TC?=?1.189-1.385; triglycerides?=?1.172-5.289). Age-stratification analysis showed that the lipid levels were lower in both the HCV-positive females aged ?49 years (TC, P?

SUBMITTER: Hu JH 

PROVIDER: S-EPMC4863783 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature

altmetric image

Publications

Sexual Dimorphic Metabolic Alterations in Hepatitis C Virus-infected Patients: A Community-Based Study in a Hepatitis B/Hepatitis C Virus Hyperendemic Area.

Hu Jing-Hong JH   Chen Mei-Yen MY   Yeh Chau-Ting CT   Lin Huang-Shen HS   Lin Ming-Shyan MS   Huang Tung-Jung TJ   Chang Ming-Ling ML  

Medicine 20160501 18


The impact of sex on metabolic alterations in individuals with hepatitis B virus (HBV) or hepatitis C virus (HCV) infection remains elusive.A community-based study was performed to assess sex, age, body mass index, the lipid profile, blood pressure, glucose, alanine aminotransferase, HBV surface antigen (HBsAg), and HCV antibody levels, smoking and alcohol drinking habits, and cardiometabolic diseases, including diabetes, hypertension, cardiovascular events, and renal diseases. The HCV-RNA level  ...[more]

Similar Datasets

| S-EPMC4072904 | biostudies-literature
| S-EPMC5199102 | biostudies-literature
| S-EPMC7959235 | biostudies-literature
| S-EPMC6707758 | biostudies-literature
| S-EPMC6128547 | biostudies-literature
| S-EPMC6646375 | biostudies-literature
| S-EPMC6405123 | biostudies-literature
| S-EPMC8764321 | biostudies-literature
| S-EPMC8481710 | biostudies-literature
2016-07-08 | PXD000988 | Pride