Increased expression of H19/miR-675 is associated with a low fat-free mass index in patients with COPD.

ABSTRACT:

Background

Loss of muscle mass and strength is a significant comorbidity in patients with chronic obstructive pulmonary disease (COPD) that limits their quality of life and has prognostic implications but does not affect everyone equally. To identify mechanisms that may contribute to the susceptibility to a low muscle mass, we investigated microRNA (miRNA) expression, methylation status, and regeneration in quadriceps muscle from COPD patients and the effect of miRNAs on myoblast proliferation in vitro. The relationships of miRNA expression with muscle mass and strength was also determined in a group of healthy older men.

Methods

We identified miRNAs associated with a low fat-free mass (FFM) phenotype in a small group of patients with COPD using a PCR screen of 750 miRNAs. T

SUBMITTER: Lewis A 

PROVIDER: S-EPMC4863928 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature