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Epigenetic dysregulation in follicular lymphoma.

ABSTRACT: The adoption of next-generation sequencing technologies has led to a remarkable shift in our understanding of the genetic landscape of follicular lymphoma. While the disease has been synonymous with the t(14;18), the prevalence of alterations in genes that regulate the epigenome has been established as a pivotal hallmark of these lymphomas. Giant strides are being made in unraveling the biological consequences of these alterations in tumorigenesis opening up new opportunities for directed therapies.

SUBMITTER: Araf S

PROVIDER: S-EPMC4864036 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature

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Epigenetic dysregulation in follicular lymphoma.

Araf Shamzah S Okosun Jessica J Koniali Lola L Fitzgibbon Jude J Heward James J

Epigenomics 20151223 1

The adoption of next-generation sequencing technologies has led to a remarkable shift in our understanding of the genetic landscape of follicular lymphoma. While the disease has been synonymous with the t(14;18), the prevalence of alterations in genes that regulate the epigenome has been established as a pivotal hallmark of these lymphomas. Giant strides are being made in unraveling the biological consequences of these alterations in tumorigenesis opening up new opportunities for directed therap ...[more]

PMID: 26698557

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