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Nanoparticle Targeting of Neutrophils for Improved Cancer Immunotherapy.

ABSTRACT: Cancer immunotherapy using tumor-specific monoclonal antibodies presents a novel approach for cancer treatment. A monoclonal antibody TA99 specific for gp75 antigen of melanoma initiates neutrophil recruitment in tumor responsible for cancer therapy. Here, a strategy is reported for hijacking neutrophils in vivo using nanoparticles (NPs) to deliver therapeutics into tumor. In a mouse model of melanoma, it is shown that systemically delivered albumin NPs increase in tumor when TA99 antibody is injected; and the NP tumor accumulation is mediated by neutrophils. After the administration of pyropheophorbide-a loaded albumin NPs and TA99, photodynamic therapy significantly suppresses the tumor growth and increases mouse survival compared with treatment with the NPs or TA99. The study reveals a new avenue to treat cancer by NP hitchhiking of immune systems to enhance delivery of therapeutics into tumor sites.

SUBMITTER: Chu D

PROVIDER: S-EPMC4864103 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature

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Nanoparticle Targeting of Neutrophils for Improved Cancer Immunotherapy.

Chu Dafeng D Zhao Qi Q Yu Jian J Zhang Faya F Zhang Hui H Wang Zhenjia Z

Advanced healthcare materials 20160317 9

Cancer immunotherapy using tumor-specific monoclonal antibodies presents a novel approach for cancer treatment. A monoclonal antibody TA99 specific for gp75 antigen of melanoma initiates neutrophil recruitment in tumor responsible for cancer therapy. Here, a strategy is reported for hijacking neutrophils in vivo using nanoparticles (NPs) to deliver therapeutics into tumor. In a mouse model of melanoma, it is shown that systemically delivered albumin NPs increase in tumor when TA99 antibody is in ...[more]

PMID: 26989887

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