Ontology highlight
ABSTRACT:
SUBMITTER: Gerits E
PROVIDER: S-EPMC4864301 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Gerits Evelien E Blommaert Eline E Lippell Anna A O'Neill Alex J AJ Weytjens Bram B De Maeyer Dries D Fierro Ana Carolina AC Marchal Kathleen K Marchand Arnaud A Chaltin Patrick P Spincemaille Pieter P De Brucker Katrijn K Thevissen Karin K Cammue Bruno P A BP Swings Toon T Liebens Veerle V Fauvart Maarten M Verstraeten Natalie N Michiels Jan J
PloS one 20160511 5
Nosocomial and community-acquired infections caused by multidrug resistant bacteria represent a major human health problem. Thus, there is an urgent need for the development of antibiotics with new modes of action. In this study, we investigated the antibacterial characteristics and mode of action of a new antimicrobial compound, SPI031 (N-alkylated 3, 6-dihalogenocarbazol 1-(sec-butylamino)-3-(3,6-dichloro-9H-carbazol-9-yl)propan-2-ol), which was previously identified in our group. This compoun ...[more]