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Neural and Behavioral Correlates of Alcohol-Induced Aggression Under Provocation.


ABSTRACT: Although alcohol consumption is linked to increased aggression, its neural correlates have not directly been studied in humans so far. Based on a comprehensive neurobiological model of alcohol-induced aggression, we hypothesized that alcohol-induced aggression would go along with increased amygdala and ventral striatum reactivity and impaired functioning of the prefrontal cortex (PFC) under alcohol. We measured neural and behavioral correlates of alcohol-induced aggression in a provoking vs non-provoking condition with a variant of the Taylor aggression paradigm (TAP) allowing to differentiate between reactive (provoked) and proactive (unprovoked) aggression. In a placebo-controlled cross-over design with moderate alcohol intoxication (~0.6 g/kg), 35 young healthy adults performed the TAP during functional magnetic resonance imaging (fMRI). Analyses revealed that provoking vs non-provoking conditions and alcohol vs placebo increased aggression and decreased brain responses in the anterior cingulate cortex/dorso-medial PFC (provoking

SUBMITTER: Gan G 

PROVIDER: S-EPMC4864624 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature

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Neural and Behavioral Correlates of Alcohol-Induced Aggression Under Provocation.

Gan Gabriela G   Sterzer Philipp P   Marxen Michael M   Zimmermann Ulrich S US   Smolka Michael N MN  

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20150514 13


Although alcohol consumption is linked to increased aggression, its neural correlates have not directly been studied in humans so far. Based on a comprehensive neurobiological model of alcohol-induced aggression, we hypothesized that alcohol-induced aggression would go along with increased amygdala and ventral striatum reactivity and impaired functioning of the prefrontal cortex (PFC) under alcohol. We measured neural and behavioral correlates of alcohol-induced aggression in a provoking vs non-  ...[more]

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