Unknown

Dataset Information

0

Excitatory Transmission to the Lateral Habenula Is Critical for Encoding and Retrieval of Spatial Memory.


ABSTRACT: The lateral habenula (LHb) is viewed as a relay between the limbic system, the basal ganglia (BG), and monoaminergic neurons of the midbrain. If a prominent role has been evidenced in BG-mediated functions such as value-based decision-making, very little is known about the involvement of the LHb in limbic functions such as memory processing. In the present study, we used two pharmacological approaches-LHb reversible inactivation with intra-LHb infusion of muscimol, an agonist of the GABA-A receptor, or blockade of excitatory inputs with intra-LHb infusion of 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), an antagonist of the glutamatergic AMPA receptor-to investigate the involvement of the LHb in encoding, consolidation, and retrieval of spatial memory in the water maze (WM) in rats. We found that intra-LHb infusion of muscimol or CNQX prevented encoding and retrieval, but not consolidation of spatial information. In addition, muscimol but not CNQX induced impairments during a cued version of the WM task, and marked anxiety in the elevated plus maze. These results confirm the involvement of the LHb in higher cognitive functions. They further suggest a dichotomy between the role of glutamatergic and other inputs to the LHb in hippocampus-dependent memory processing, as well as in emotional aspects of goal-directed behaviors.

SUBMITTER: Mathis V 

PROVIDER: S-EPMC4864662 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature

altmetric image

Publications

Excitatory Transmission to the Lateral Habenula Is Critical for Encoding and Retrieval of Spatial Memory.

Mathis Victor V   Cosquer Brigitte B   Avallone Martino M   Cassel Jean-Christophe JC   Lecourtier Lucas L  

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20150514 12


The lateral habenula (LHb) is viewed as a relay between the limbic system, the basal ganglia (BG), and monoaminergic neurons of the midbrain. If a prominent role has been evidenced in BG-mediated functions such as value-based decision-making, very little is known about the involvement of the LHb in limbic functions such as memory processing. In the present study, we used two pharmacological approaches-LHb reversible inactivation with intra-LHb infusion of muscimol, an agonist of the GABA-A recep  ...[more]

Similar Datasets

| S-EPMC5380958 | biostudies-literature
| S-EPMC3799061 | biostudies-literature
| S-EPMC5835141 | biostudies-literature
| S-EPMC4817146 | biostudies-other
| S-EPMC5699228 | biostudies-literature
| S-EPMC6456292 | biostudies-literature
| S-EPMC2920878 | biostudies-literature
| S-EPMC5009114 | biostudies-literature
| S-EPMC10045719 | biostudies-literature
| S-EPMC3471532 | biostudies-literature