Hypomethylation of FAM63B in bipolar disorder patients.
Ontology highlight
ABSTRACT:
SUBMITTER: Starnawska A
PROVIDER: S-EPMC4865008 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Publications
Hypomethylation of FAM63B in bipolar disorder patients.
Starnawska Anna A Demontis Ditte D McQuillin Andrew A O'Brien Niamh L NL Staunstrup Nicklas H NH Mors Ole O Nielsen Anders L AL Børglum Anders D AD Nyegaard Mette M
Clinical epigenetics 20160511
Bipolar disorder (BD) and schizophrenia (SZ) are known to share common genetic and psychosocial risk factors. A recent epigenome-wide association study performed on blood samples from SZ patients found significant hypomethylation of FAM63B in exon 9. Here, we used iPLEX-based methylation analysis to investigate two CpG sites in FAM63B in blood samples from 459 BD cases and 268 controls. Both sites were significantly hypomethylated in BD cases (lowest p value = 3.94 × 10(-8)). The methylation lev ...[more]
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