Ontology highlight
ABSTRACT:
SUBMITTER: Kristian SA
PROVIDER: S-EPMC4865217 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Kristian Sascha A SA Ota Takayuki T Bubeck Sarah S SS Cho Rebecca R Groff Brian C BC Kubota Tsuguo T Destito Giuseppe G Martin Cécile C Laudenslager John J Koriazova Lilia L Tahara Tomoyuki T Kanda Yutaka Y
PloS one 20160512 5
A proof-of-concept study evaluating the potential of Streptococcus pneumoniae Pneumococcal Surface Protein A (PspA) as a passive immunization target was conducted. We describe the generation and isolation of several broadly reactive mouse anti-PspA monoclonal antibodies (mAbs). MAb 140H1 displayed (i) 98% strain coverage, (ii) activity in complement deposition and opsonophagocytic killing (OPK) assays, which are thought to predict the in vivo efficacy of anti-pneumococcal mAbs, (iii) efficacy in ...[more]