Dataset Information

Sleep Apnea Is Associated with Hearing Impairment: The Hispanic Community Health Study/Study of Latinos.

ABSTRACT:

Study objective

Sleep apnea (SA) may promote hearing impairment (HI) through ischemia and inflammation of the cochlea. Our objective was to assess an independent association between SA and HI in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) participants.

Methods

We used data from the HCHS/SOL, a multicenter population-based study of self- identifying Hispanic/Latinos 18- to 74-y-old adults from four US urban communities. We performed home SA testing and in-clinic audiometry testing in all participants. SA was defined as an apnea-hypopnea index (AHI) ? 15 events/h. HI was defined as a mean hearing threshold > 25 dB hearing level in either ear at the frequencies: 3,000 to 8,000 Hz for high-frequency HI (HF-HI) and 500 to 2,000 Hz for low-frequency HI (LF-HI). Combined-frequency HI (CF-HI) was defined as both conditions present, and Any-HI was considered as HI in either low or high frequencies.

Results

Of 13,967 participants, 9.9% had SA and 32.3% had Any-HI. Adjusted for risk factors for HI, those with SA had a 30% higher odds of Any-HI (95% confidence interval [CI] = 8% to 57%), 26% higher odds of HF-HI (CI = 3% to 55%), 127% higher odds of LF-HI (CI = 21% to 326%), and 29% higher odds of CF-HI (CI = 0% to 65%). A dose-response association was observed between AHI severity and Any-HI (versus no SA, OR for AHI ? 15 and < 30 = 1.22, CI = 0.96 to 1.54, and OR for AHI ? 30 = 1.46, CI = 1.11 to 1.91, p = 0.002).

Conclusion

SA is associated with HF-HI and LF-HI, independent of snoring and other confounders.

Commentary

A commentary on this article appears in this issue on page 641.

SUBMITTER: Chopra A

PROVIDER: S-EPMC4865559 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature

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Publications

Sleep Apnea Is Associated with Hearing Impairment: The Hispanic Community Health Study/Study of Latinos.

Chopra Amit A Jung Molly M Kaplan Robert C RC Appel David W DW Dinces Elizabeth A EA Dhar Sumitrajit S Zee Phyllis C PC Gonzalez Franklyn F Lee David J DJ Ramos Alberto R AR Hoffman Howard J HJ Redline Susan S Cruickshanks Karen J KJ Shah Neomi A NA

Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine 20160515 5

<h4>Study objective</h4>Sleep apnea (SA) may promote hearing impairment (HI) through ischemia and inflammation of the cochlea. Our objective was to assess an independent association between SA and HI in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) participants.<h4>Methods</h4>We used data from the HCHS/SOL, a multicenter population-based study of self- identifying Hispanic/Latinos 18- to 74-y-old adults from four US urban communities. We performed home SA testing and in-clinic ...[more]

PMID: 26951413

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Project description:BACKGROUND:Sleep apnea and diabetes mellitus (DM) negatively impact cardiovascular health. One important indicator of cardiovascular health is the Ankle-Brachial Index (ABI). Either low ABI or high ABI are signs of peripheral vascular impairment. Impaired vascular health and DM, together, might provoke sleep apnea; however, information regarding these relationships is limited. Therefore, this study aimed to investigate the association between ABI, DM status, and severity of obstructive sleep apnea in people of Hispanic/Latino descent who are diverse in culture, environmental exposures, nativity, socioeconomic status, and disease burden. METHODS:A cross sectional analysis from a multi-center epidemiologic study, Hispanic Community Health Study/Study of Latinos, was utilized and included 3779 participants (mean age 55.32?±?7.67, females 57.9%). The sample was divided into 4 groups based on the American Diabetes Association diagnostic guidelines (no DM or DM), and the ABI status (normal and abnormal). Multiple linear regression analysis was used to determine the association of the four groups and other independent variables with severity of sleep apnea measured by apnea-hypopnea index. Kruskal-Wallis H test was used for comparisons between groups for the apnea-hypopnea index. The significant level was set at 0.01. RESULTS:There were significant differences between groups in the mean of apnea-hypopnea index (P?<?0.001; no DM?+?normal ABI?=?5.42?±?9.66, no DM?+?abnormal ABI?=?7.11?±?11.63, DM?+?normal ABI?=?10.99?±?15.16, DM?+?abnormal ABI?=?12.81?±?17.80). Linear regression showed that DM and abnormal ABI were significantly associated with severe sleep apnea (??=?3.25, P?=?0.001) after controlling for age, sex, BMI, income, education, alcohol use, cigarette use, hypertension or related medication, stroke and statin use. CONCLUSION:These findings suggest that people with DM and abnormal ABI were more likely to have high apnea-hypopnea index compared to the other groups. We observed gradual increasing in the severity of sleep apnea from low abnormality groups to high abnormality groups for Hispanic/Latino. Further work should elucidate the association of DM, abnormal ABI and sleep apnea with longer term outcomes, and replicate this work in different populations.

Dataset Information

Sleep Apnea Is Associated with Hearing Impairment: The Hispanic Community Health Study/Study of Latinos.

Study objective

Methods

Results

Conclusion

Commentary

Publications

Sleep Apnea Is Associated with Hearing Impairment: The Hispanic Community Health Study/Study of Latinos.

Similar Datasets

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