Ontology highlight
ABSTRACT:
SUBMITTER: Goto Y
PROVIDER: S-EPMC4865980 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Goto Yusuke Y Kojima Satoko S Kurozumi Akira A Kato Mayuko M Okato Atsushi A Matsushita Ryosuke R Ichikawa Tomohiko T Seki Naohiko N
British journal of cancer 20160412 10
<h4>Background</h4>MicroRNA-224 (miR-224) and microRNA-452 (miR-452) are closely located on the human chromosome Xq28 region. miR-224 functions as a tumour suppressor by targeting tumour protein D52 (TPD52) in prostate cancer (PCa). Here, we aimed to investigate the functional significance of miR-452 in PCa cells.<h4>Methods</h4>Functional studies of PCa cells were performed using transfection with mature miRNAs or siRNAs. Genome-wide gene expression analysis, in silico analysis, and dual-lucife ...[more]