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Liver-derived human mesenchymal stem cells: a novel therapeutic source for liver diseases.

ABSTRACT: Mesenchymal stem cells (MSCs) represent an attractive cell type for research and therapy due to their ability to proliferate, differentiate, modulate immune reactions, and secrete trophic factors. MSCs exist in a multitude of tissues, including bone marrow, umbilical cord, and adipose tissues. Moreover, MSCs have recently been isolated from the liver. Compared with other MSC types, liver-derived human MSCs (LHMSCs) possess general morphologies, immune functions, and differentiation capacities. Interestingly, LHMCSs produce higher levels of pro-angiogenic, anti-inflammatory, and anti-apoptotic cytokines than those of bone marrow-derived MSCs. Thus, these cells may be a promising therapeutic source for liver diseases. This paper summarizes the biological characteristics of LHMSCs and their potential benefits and risks for the treatment of liver diseases.

SUBMITTER: Wang Y

PROVIDER: S-EPMC4866276 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature

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Liver-derived human mesenchymal stem cells: a novel therapeutic source for liver diseases.

Wang Yini Y Yu Xiaopeng X Chen Ermei E Li Lanuan L

Stem cell research & therapy 20160512 1

Mesenchymal stem cells (MSCs) represent an attractive cell type for research and therapy due to their ability to proliferate, differentiate, modulate immune reactions, and secrete trophic factors. MSCs exist in a multitude of tissues, including bone marrow, umbilical cord, and adipose tissues. Moreover, MSCs have recently been isolated from the liver. Compared with other MSC types, liver-derived human MSCs (LHMSCs) possess general morphologies, immune functions, and differentiation capacities. I ...[more]

PMID: 27176654

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