Ontology highlight
ABSTRACT:
SUBMITTER: Trost BM
PROVIDER: S-EPMC4866641 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20160309 11
Herein, we report a Zn-ProPhenol catalyzed Mannich reaction using α-branched ketones as nucleophilic partners for the direct enantio- and diastereoselective construction of quaternary carbon stereocenters. The reaction can be run on a gram-scale with a low catalyst loading without impacting its efficiency. Moreover, the Mannich adducts can be further elaborated with complete diastereocontrol to access molecules possessing complex stereotriads. ...[more]