Ontology highlight
ABSTRACT:
SUBMITTER: Sehgal SA
PROVIDER: S-EPMC4866741 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Sehgal Sheikh Arslan SA Mannan Shazia S Ali Sannia S
Drug design, development and therapy 20160506
Charcot-Marie-Tooth (CMT) disease is an inherited peripheral neuromuscular disorder characterized by length-dependent and progressive degeneration of peripheral nerves, leading to muscular weakness. Research has shown that mutated HSPB8 may be responsible for depression, neurodegenerative disorders, and improper functioning of peripheral nerves, resulting in neuromuscular disorders like CMT. In the current work, a hybrid approach of virtual screening and molecular docking studies was followed by ...[more]