Ontology highlight
ABSTRACT:
SUBMITTER: Chen L
PROVIDER: S-EPMC4866761 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Chen Lihua L DeWispelaere Allison A Dastvan Frank F Osborne William R A WR Blechner Christine C Windhorst Sabine S Daum Guenter G
PloS one 20160513 5
Smooth muscle alpha-actin (SMA) is a marker for the contractile, non-proliferative phenotype of adult smooth muscle cells (SMCs). Upon arterial injury, expression of SMA and other structural proteins decreases and SMCs acquire a pro-migratory and proliferative phenotype. To what extent SMA regulates migration and proliferation of SMCs is unclear and putative signaling pathways involved remain to be elucidated. Here, we used lentiviral-mediated gene transfer and siRNA technology to manipulate exp ...[more]