Bullied no more: when and how DNA shoves proteins around.
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ABSTRACT:
SUBMITTER: Fogg JM
PROVIDER: S-EPMC4866820 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Publications
Bullied no more: when and how DNA shoves proteins around.
Fogg Jonathan M JM Randall Graham L GL Pettitt B Montgomery BM Sumners De Witt L WL Harris Sarah A SA Zechiedrich Lynn L
Quarterly reviews of biophysics 20120731 3
The predominant protein-centric perspective in protein-DNA-binding studies assumes that the protein drives the interaction. Research focuses on protein structural motifs, electrostatic surfaces and contact potentials, while DNA is often ignored as a passive polymer to be manipulated. Recent studies of DNA topology, the supercoiling, knotting, and linking of the helices, have shown that DNA has the capability to be an active participant in its transactions. DNA topology-induced structural and geo ...[more]
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