Ontology highlight
ABSTRACT:
SUBMITTER: Campos CA
PROVIDER: S-EPMC4867080 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Campos Carlos A CA Bowen Anna J AJ Schwartz Michael W MW Palmiter Richard D RD
Cell metabolism 20160501 5
The lateral parabrachial nucleus is a conduit for visceral signals that cause anorexia. We previously identified a subset of neurons located in the external lateral parabrachial nucleus (PBel) that express calcitonin gene-related peptide (CGRP) and inhibit feeding when activated by illness mimetics. We report here that in otherwise normal mice, functional inactivation of CGRP neurons markedly increases meal size, with meal frequency being reduced in a compensatory manner, and renders mice insens ...[more]