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Electronic structure contributions to reactivity in xanthine oxidase family enzymes.

ABSTRACT: We review the xanthine oxidase (XO) family of pyranopterin molybdenum enzymes with a specific emphasis on electronic structure contributions to reactivity. In addition to xanthine and aldehyde oxidoreductases, which catalyze the two-electron oxidation of aromatic heterocycles and aldehyde substrates, this mini-review highlights recent work on the closely related carbon monoxide dehydrogenase (CODH) that catalyzes the oxidation of CO using a unique Mo-Cu heterobimetallic active site. A primary focus of this mini-review relates to how spectroscopy and computational methods have been used to develop an understanding of critical relationships between geometric structure, electronic structure, and catalytic function.

SUBMITTER: Stein BW

PROVIDER: S-EPMC4867223 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature

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Electronic structure contributions to reactivity in xanthine oxidase family enzymes.

Stein Benjamin W BW Kirk Martin L ML

Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20141126 2

We review the xanthine oxidase (XO) family of pyranopterin molybdenum enzymes with a specific emphasis on electronic structure contributions to reactivity. In addition to xanthine and aldehyde oxidoreductases, which catalyze the two-electron oxidation of aromatic heterocycles and aldehyde substrates, this mini-review highlights recent work on the closely related carbon monoxide dehydrogenase (CODH) that catalyzes the oxidation of CO using a unique Mo-Cu heterobimetallic active site. A primary fo ...[more]

PMID: 25425163

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