Ontology highlight
ABSTRACT:
SUBMITTER: Ontoria JM
PROVIDER: S-EPMC4867480 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
ACS medicinal chemistry letters 20160305 5
The identification of a new series of P. falciparum growth inhibitors is described. Starting from a series of known human class I HDAC inhibitors a SAR exploration based on growth inhibitory activity in parasite and human cells-based assays led to the identification of compounds with submicromolar inhibition of P. falciparum growth (EC50 < 500 nM) and good selectivity over the activity of human HDAC in cells (up to >50-fold). Inhibition of parasital HDACs as the mechanism of action of this new c ...[more]