Ontology highlight
ABSTRACT:
SUBMITTER: Hatcher JM
PROVIDER: S-EPMC4867484 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Hatcher John M JM Weisberg Ellen E Sim Taebo T Stone Richard M RM Liu Suiyang S Griffin James D JD Gray Nathanael S NS
ACS medicinal chemistry letters 20160308 5
For a subpopulation of acute myeloid leukemia (AML) patients, the mutationally activated tyrosine kinase FLT3, has emerged as a promising target for therapy. The development of drug resistance due to mutation is a growing concern for mutant FLT3 inhibitors, such as PKC412, Quizartinib, PLX3397, and Crenolanib. Thus, there is a need to develop novel FLT3 inhibitors that overcome these mutations. Here we report the development of a novel type I ATP competitive inhibitor, JH-IX-179, that is extreme ...[more]