Ontology highlight
ABSTRACT:
SUBMITTER: Lee SY
PROVIDER: S-EPMC4867646 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Lee Shin Yup SY Jung Deuk Kju DK Choi Jin Eun JE Jin Cheng Cheng CC Hong Mi Jeong MJ Do Sook Kyung SK Kang Hyo-Gyoung HG Lee Won Kee WK Seok Yangki Y Lee Eung Bae EB Jeong Ji Yun JY Shin Kyung Min KM Yoo Seung Soo SS Lee Jaehee J Cha Seung Ick SI Kim Chang Ho CH Park Jae Yong JY
Scientific reports 20160516
This study was conducted to investigate whether polymorphisms of genes involved in immune checkpoints can predict the clinical outcomes of patients with advanced stage non-small cell lung cancer (NSCLC) after 1st line paclitaxel-cisplatin chemotherapy. A total of 379 NSCLC patients were enrolled. Twelve single nucleotide polymorphisms (SNPs) of PD-1, PD-L1, and CTLA-4 genes were selected and genotyped. The associations of SNPs with chemotherapy response and overall survival (OS) were analyzed. A ...[more]