Ontology highlight
ABSTRACT:
SUBMITTER: Buclez PO
PROVIDER: S-EPMC4867670 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Buclez Pierre-Olivier PO Dias Florencio Gabriella G Relizani Karima K Beley Cyriaque C Garcia Luis L Benchaouir Rachid R
Molecular therapy. Methods & clinical development 20160511
Recombinant adeno-associated viruses (rAAV) are largely used for gene transfer in research, preclinical developments, and clinical trials. Their broad in vivo biodistribution and long-term efficacy in postmitotic tissues make them good candidates for numerous gene transfer applications. Upstream processes able to produce large amounts of rAAV were developed, particularly those using baculovirus expression vector system. In parallel, downstream processes present a large panel of purification meth ...[more]