Ontology highlight
ABSTRACT:
SUBMITTER: Fu AK
PROVIDER: S-EPMC4868478 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Fu Amy K Y AK Hung Kwok-Wang KW Yuen Michael Y F MY Zhou Xiaopu X Mak Deejay S Y DS Chan Ivy C W IC Cheung Tom H TH Zhang Baorong B Fu Wing-Yu WY Liew Foo Y FY Ip Nancy Y NY
Proceedings of the National Academy of Sciences of the United States of America 20160418 19
Alzheimer's disease (AD) is a devastating condition with no known effective treatment. AD is characterized by memory loss as well as impaired locomotor ability, reasoning, and judgment. Emerging evidence suggests that the innate immune response plays a major role in the pathogenesis of AD. In AD, the accumulation of β-amyloid (Aβ) in the brain perturbs physiological functions of the brain, including synaptic and neuronal dysfunction, microglial activation, and neuronal loss. Serum levels of solu ...[more]