Ontology highlight
ABSTRACT:
SUBMITTER: Rozovski U
PROVIDER: S-EPMC4868805 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Rozovski Uri U Harris David M DM Li Ping P Liu Zhiming Z Wu Ji Yuan JY Grgurevic Srdana S Faderl Stefan S Ferrajoli Alessandra A Wierda William G WG Martinez Matthew M Verstovsek Srdan S Keating Michael J MJ Estrov Zeev Z
Journal of immunology (Baltimore, Md. : 1950) 20160413 10
In chronic lymphocytic leukemia (CLL), the increment in PBLs is slower than the expected increment calculated from the cells' proliferation rate, suggesting that cellular proliferation and apoptosis are concurrent. Exploring this phenomenon, we found overexpression of caspase-3, higher cleaved poly (ADP-ribose) polymerase levels (p < 0.007), and a higher apoptosis rate in cells from patients with high counts compared with cells from patients with low counts. Although we previously found that STA ...[more]