Ontology highlight
ABSTRACT:
SUBMITTER: Forneris F
PROVIDER: S-EPMC4868954 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Forneris Federico F Wu Jin J Xue Xiaoguang X Ricklin Daniel D Lin Zhuoer Z Sfyroera Georgia G Tzekou Apostolia A Volokhina Elena E Granneman Joke Cm JC Hauhart Richard R Bertram Paula P Liszewski M Kathryn MK Atkinson John P JP Lambris John D JD Gros Piet P
The EMBO journal 20160324 10
Regulators of complement activation (RCA) inhibit complement-induced immune responses on healthy host tissues. We present crystal structures of human RCA (MCP, DAF, and CR1) and a smallpox virus homolog (SPICE) bound to complement component C3b. Our structural data reveal that up to four consecutive homologous CCP domains (i-iv), responsible for inhibition, bind in the same orientation and extended arrangement at a shared binding platform on C3b. Large sequence variations in CCP domains explain ...[more]