Ontology highlight
ABSTRACT:
SUBMITTER: Li J
PROVIDER: S-EPMC4869026 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Li Jie J Xia Wei W Su Xueting X Qin Xingliang X Chen Ying Y Li Shaohua S Dong Jie J Ding Hongmei H Li Hui H Huang Aixue A Ge Xingfeng X Hou Lvbin L Wang Chaonan C Sun Leqiao L Bai Chenjun C Shen Xuelian X Fang Tao T Liu Yuanlin Y Zhang Yi Y Zhang Hongru H Zhang Hongwen H Shao Ningsheng N
Scientific reports 20160517
In recent years, p53 was identified to regulate the expression of many miRNAs and was also regulated by miRNAs. In this paper, we found that miR-138 showed a pronounced increase after p53 activation in human non-small cell lung cancer (NSCLC) cells, which is mediated by p53 binding sites in the promoter region of its host gene, but this did not happen with rat and mouse cells. More interestingly, we found that p53 could be also regulated by miR-138 in mouse and rat cells, but not in the human NS ...[more]