Ontology highlight
ABSTRACT:
SUBMITTER: Liu S
PROVIDER: S-EPMC4869123 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Liu Shenping S Desharnais Joel J Sahasrabudhe Parag V PV Jin Ping P Li Wei W Oates Bryan D BD Shanker Suman S Banker Mary Ellen ME Chrunyk Boris A BA Song Xi X Feng Xidong X Griffor Matt M Jimenez Judith J Chen Gang G Tumelty David D Bhat Abhijit A Bradshaw Curt W CW Woodnutt Gary G Lappe Rodney W RW Thorarensen Atli A Qiu Xiayang X Withka Jane M JM Wood Lauren D LD
Scientific reports 20160517
IL-17A is a pro-inflammatory cytokine that has been implicated in autoimmune and inflammatory diseases. Monoclonal antibodies inhibiting IL-17A signaling have demonstrated remarkable efficacy, but an oral therapy is still lacking. A high affinity IL-17A peptide antagonist (HAP) of 15 residues was identified through phage-display screening followed by saturation mutagenesis optimization and amino acid substitutions. HAP binds specifically to IL-17A and inhibits the interaction of the cytokine wit ...[more]