Ontology highlight
ABSTRACT:
SUBMITTER: Boldt K
PROVIDER: S-EPMC4869170 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Boldt Karsten K van Reeuwijk Jeroen J Lu Qianhao Q Koutroumpas Konstantinos K Nguyen Thanh-Minh T TM Texier Yves Y van Beersum Sylvia E C SE Horn Nicola N Willer Jason R JR Mans Dorus A DA Dougherty Gerard G Lamers Ideke J C IJ Coene Karlien L M KL Arts Heleen H HH Betts Matthew J MJ Beyer Tina T Bolat Emine E Gloeckner Christian Johannes CJ Haidari Khatera K Hetterschijt Lisette L Iaconis Daniela D Jenkins Dagan D Klose Franziska F Knapp Barbara B Latour Brooke B Letteboer Stef J F SJ Marcelis Carlo L CL Mitic Dragana D Morleo Manuela M Oud Machteld M MM Riemersma Moniek M Rix Susan S Terhal Paulien A PA Toedt Grischa G van Dam Teunis J P TJ de Vrieze Erik E Wissinger Yasmin Y Wu Ka Man KM Apic Gordana G Beales Philip L PL Blacque Oliver E OE Gibson Toby J TJ Huynen Martijn A MA Katsanis Nicholas N Kremer Hannie H Omran Heymut H van Wijk Erwin E Wolfrum Uwe U Kepes François F Davis Erica E EE Franco Brunella B Giles Rachel H RH Ueffing Marius M Russell Robert B RB Russell Robert B RB Roepman Ronald R
Nature communications 20160513
Cellular organelles provide opportunities to relate biological mechanisms to disease. Here we use affinity proteomics, genetics and cell biology to interrogate cilia: poorly understood organelles, where defects cause genetic diseases. Two hundred and seventeen tagged human ciliary proteins create a final landscape of 1,319 proteins, 4,905 interactions and 52 complexes. Reverse tagging, repetition of purifications and statistical analyses, produce a high-resolution network that reveals organelle- ...[more]