MiR-216b regulation of c-Jun mediates GADD153/CHOP-dependent apoptosis.
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ABSTRACT:
SUBMITTER: Xu Z
PROVIDER: S-EPMC4869177 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Publications
miR-216b regulation of c-Jun mediates GADD153/CHOP-dependent apoptosis.
Xu Zhenhua Z Bu Yiwen Y Chitnis Nilesh N Koumenis Costas C Fuchs Serge Y SY Diehl J Alan JA
Nature communications 20160513
The ability of the unfolded protein response, UPR, to regulate cell homeostasis through both gene expression and protein synthesis has been well documented. One primary pro-apoptotic protein that responds to both PERK and Ire1 signalling is the CHOP/GADD153 transcription factor. Although CHOP deficiency delays onset of cell death, questions remain regarding how CHOP regulates apoptosis. Here, we provide evidence demonstrating that CHOP/GADD153-dependent apoptosis reflects expression of micro-RNA ...[more]
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