Molecular profile of dissociative drug ketamine in relation to its rapid antidepressant action.
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ABSTRACT:
SUBMITTER: Ficek J
PROVIDER: S-EPMC4869301 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Publications
Molecular profile of dissociative drug ketamine in relation to its rapid antidepressant action.
Ficek Joanna J Zygmunt Magdalena M Piechota Marcin M Hoinkis Dzesika D Rodriguez Parkitna Jan J Przewlocki Ryszard R Korostynski Michal M
BMC genomics 20160517
<h4>Background</h4>The NMDA receptor antagonist ketamine was found to act as a fast-acting antidepressant. The effects of single treatment were reported to persist for days to weeks, even in otherwise treatment-refractory cases. Identification of the mechanisms underlying ketamine's antidepressant action may permit development of novel drugs, with similar clinical properties but lacking psychotomimetic, sedative and other side effects.<h4>Methods</h4>We applied whole-genome microarray profiling ...[more]
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