Agonist anti-GITR monoclonal antibody and stereotactic radiation induce immune-mediated survival advantage in murine intracranial glioma.
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ABSTRACT:
SUBMITTER: Patel MA
PROVIDER: S-EPMC4869343 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Publications
Agonist anti-GITR monoclonal antibody and stereotactic radiation induce immune-mediated survival advantage in murine intracranial glioma.
Patel Mira A MA Kim Jennifer E JE Theodros Debebe D Tam Ada A Velarde Esteban E Kochel Christina M CM Francica Brian B Nirschl Thomas R TR Ghasemzadeh Ali A Mathios Dimitrios D Harris-Bookman Sarah S Jackson Christopher C CC Jackson Christina C Ye Xiaobu X Tran Phuoc T PT Tyler Betty B Coric Vladimir V Selby Mark M Brem Henry H Drake Charles G CG Pardoll Drew M DM Lim Michael M
Journal for immunotherapy of cancer 20160517
<h4>Background</h4>Glioblastoma (GBM) is a poorly immunogenic neoplasm treated with focused radiation. Immunotherapy has demonstrated synergistic survival effects with stereotactic radiosurgery (SRS) in murine GBM. GITR is a co-stimulatory molecule expressed constitutively on regulatory T-cells and by effector T-cells upon activation. We tested the hypothesis that anti-GITR monoclonal antibody (mAb) and SRS together would confer an immune-mediated survival benefit in glioma using the orthotopic ...[more]
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