Ontology highlight
ABSTRACT:
SUBMITTER: Toledo LI
PROVIDER: S-EPMC4869831 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Toledo Luis I LI Murga Matilde M Zur Rafal R Soria Rebeca R Rodriguez Antonio A Martinez Sonia S Oyarzabal Julen J Pastor Joaquin J Bischoff James R JR Fernandez-Capetillo Oscar O
Nature structural & molecular biology 20110508 6
Oncogene activation has been shown to generate replication-born DNA damage, also known as replicative stress. The primary responder to replicative stress is not Ataxia-Telangiectasia Mutated (ATM) but rather the kinase ATM and Rad3-related (ATR). One limitation for the study of ATR is the lack of potent inhibitors. We here describe a cell-based screening strategy that has allowed us to identify compounds with ATR inhibitory activity in the nanomolar range. Pharmacological inhibition of ATR gener ...[more]