Ontology highlight
ABSTRACT:
SUBMITTER: Depry C
PROVIDER: S-EPMC4870014 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Depry Charlene C Mehta Sohum S Li Ruojing R Zhang Jin J
Chemistry & biology 20151105 11
The ability to monitor kinase activity dynamics in live cells greatly aids the study of how signaling events are spatiotemporally regulated. Here, we report on the adaptability of bimolecular kinase activity reporters (bimKARs) as molecular tools to enhance the real-time visualization of kinase activity. We demonstrate that the bimKAR design is truly versatile and can be used to monitor a variety of kinases, including JNK, ERK, and AMPK. Furthermore, bimKARs can have significantly enhanced dynam ...[more]