Dataset Information

Relationship Between Binocular Summation and Stereoacuity After Strabismus Surgery.

ABSTRACT: To describe the relationship between binocular summation and stereoacuity after strabismus surgery.Prospective case series.setting: Stein Eye Institute, University of California Los Angeles.Pediatric strabismic patients who underwent strabismus surgery between 2010 and 2015.Early Treatment Diabetic Retinopathy Study visual acuity, Sloan low-contrast acuity (LCA, 2.5% and 1.25%), and Randot stereoacuity 2 months following surgical correction of strabismus.The relationship between binocular summation (BiS), calculated as the difference between the binocular visual acuity score and that of the better eye, and stereoacuity.A total of 130 postoperative strabismic patients were studied. The relationship between binocular summation and stereoacuity was studied by Spearman correlation. There were significant correlations between BiS for 2.5% LCA with near and distance stereoacuity (P = .006 and P = .009). BiS for 1.25% LCA was also significantly correlated with near stereoacuity (P = .04). Near stereoacuity and BiS for 2.5% and 1.25% LCA were significantly dependent (Pearson ?(2), P = .006 and P = .026). Patients with stereoacuity demonstrated significantly more BiS in 2.5% LCA of 2.7 (P = .022) and 3.1 (P = .014) letters than did those without near or distance stereoacuity, respectively.These findings demonstrate that stereopsis and binocular summation are significantly correlated in patients who have undergone surgical correction of strabismus.

SUBMITTER: Kattan JM

PROVIDER: S-EPMC4870145 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature

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Relationship Between Binocular Summation and Stereoacuity After Strabismus Surgery.

Kattan Jaffer M JM Velez Federico G FG Demer Joseph L JL Pineles Stacy L SL

American journal of ophthalmology 20160226

<h4>Purpose</h4>To describe the relationship between binocular summation and stereoacuity after strabismus surgery.<h4>Design</h4>Prospective case series.<h4>Methods</h4>setting: Stein Eye Institute, University of California Los Angeles.<h4>Patient population</h4>Pediatric strabismic patients who underwent strabismus surgery between 2010 and 2015.<h4>Observation procedures</h4>Early Treatment Diabetic Retinopathy Study visual acuity, Sloan low-contrast acuity (LCA, 2.5% and 1.25%), and Randot st ...[more]

PMID: 26921805

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Project description:Binocular summation (BiS) is defined as the superiority of visual function for binocular over monocular viewing. Binocular summation decreases with age and large interocular differences in visual acuity. To our knowledge, BiS has not heretofore been well studied as a functional measure of binocularity in strabismus.To evaluate the effect of strabismus on BiS using a battery of psychophysical tasks that are clinically relevant and easy to use and to determine whether strabismus is associated with binocular inhibition in extreme cases.Case-control study.University-based eye institute.Strabismic patients recruited during 2010 to 2012 from a preoperative clinic and control participants with no history of eye disease other than refractive error.A battery of psychophysical and electrophysiological tests including Early Treatment Diabetic Retinopathy Study visual acuity, Sloan low-contrast acuity (LCA) (2.5% and 1.25%), Pelli-Robson contrast sensitivity, and sweep visual evoked potential contrast sensitivity.Binocular summation was calculated as the ratio between binocular and better-eye individual scores.Sixty strabismic and 80 control participants were prospectively examined (age range, 8-60 years). Mean BiS was significantly lower in the strabismic patients than controls for LCA (2.5% and 1.25%, P = .005 and <.001, respectively). For 1.25% LCA, strabismic patients had a mean BiS score less than 1, indicating binocular inhibition (ie, the binocular score was less than that of the better eye's monocular score). There was no significant difference in BiS for contrast thresholds on Early Treatment Diabetic Retinopathy Study visual acuity, Pelli-Robson contrast sensitivity, or sweep visual evoked potential contrast sensitivity. Regression analysis revealed a significant worsening of BiS with strabismus for 2.5% (P = .009) and 1.25% (P = .002) LCA, after accounting for age.Strabismic patients demonstrate subnormal BiS and even binocular inhibition for LCA, suggesting that strabismus impairs visual function more than previously appreciated. This may explain why strabismic patients who are not diplopic close 1 eye in visually demanding situations. This finding clarifies the visual deficits impacting quality of life in strabismic patients and may represent a novel measure by which to evaluate and monitor function in strabismus.

Project description:ImportanceCurrent clinical methods for assessing strabismus can be prone to error. Binocular optical coherence tomography (OCT) has the potential to assess and quantify strabismus objectively and in an automated manner.ObjectiveTo evaluate the use of a binocular OCT prototype to assess the presence and size of strabismus.Design, setting, and participantsFifteen participants with strabismus were recruited in 2016 as part of the EASE study from Moorfields Eye Hospital National Health Service Foundation Trust, London, England, and 15 healthy volunteers underwent automated anterior segment imaging using the binocular OCT prototype. All participants had an orthoptic assessment, including alternating prism cover test (APCT), before undergoing imaging. Simultaneously acquired pairs of OCT images, captured with 1 eye fixating, were analyzed using ImageJ (National Institutes of Health) to assess the presence and angle of strabismus.Main outcomes and measuresThe direction and size of strabismus measured using binocular OCT was compared with that found using APCT.ResultsThe median age for participants with strabismus was 55 years (interquartile range [IQR], 33-66.5 years) and for the healthy group, 50 years (IQR, 41-59 years); 15 participants (50%) were women, and 25 participants (83.3%) were white. The median magnitude of horizontal deviation was 20∆ (IQR, 13-35∆) and for vertical deviation, 3∆ (IQR, 0-5∆). Binocular OCT imaging correctly revealed the type and direction of the deviation in all 15 participants with strabismus, including horizontal and vertical deviations. The APCT and OCT measurements were strongly correlated for the horizontal (Pearson r = 0.85; 95% CI, 0.60-0.95; P < .001) and vertical (r = 0.89; 95% CI, 0.69-0.96; P < .001) deviations. In the healthy cohort, 9 of 15 participants (60%) had a latent horizontal deviation on APCT results (median magnitude 2∆, range 2-4∆). Six (40%) had orthophoria. Horizontal deviations were observed on OCT imaging results in 12 of the 15 participants (80%), and a vertical deviation was visible in 1 participant (6.7%).Conclusions and relevanceThese findings suggest that binocular anterior segment OCT imaging can provide clinicians with a precise measurement of strabismus. The prototype can potentially incorporate several binocular vision tests that will provide quantitative data for the assessment, diagnosis, and monitoring of ocular misalignments.

Dataset Information

Relationship Between Binocular Summation and Stereoacuity After Strabismus Surgery.

Publications

Relationship Between Binocular Summation and Stereoacuity After Strabismus Surgery.

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