Ontology highlight
ABSTRACT:
SUBMITTER: Jaenisch N
PROVIDER: S-EPMC4870642 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Jaenisch Nadine N Liebmann Lutz L Guenther Madlen M Hübner Christian A CA Frahm Christiane C Witte Otto W OW
Scientific reports 20160518
Stroke survivors often recover from motor deficits, either spontaneously or with the support of rehabilitative training. Since tonic GABAergic inhibition controls network excitability, it may be involved in recovery. Middle cerebral artery occlusion in rodents reduces tonic GABAergic inhibition in the structurally intact motor cortex (M1). Transcript and protein abundance of the extrasynaptic GABAA-receptor complex α4β3δ are concurrently reduced (δ-GABAARs). In vivo and in vitro analyses show th ...[more]