An attenuated virus vaccine appears safe to the central nervous system of rainbow trout (Oncorhynchus mykiss) after intranasal delivery.
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ABSTRACT:
SUBMITTER: Larragoite ET
PROVIDER: S-EPMC4871134 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
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An attenuated virus vaccine appears safe to the central nervous system of rainbow trout (Oncorhynchus mykiss) after intranasal delivery.
Larragoite Erin T ET Tacchi Luca L LaPatra Scott E SE Salinas Irene I
Fish & shellfish immunology 20160106
Nasal vaccines are very effective but the olfactory organ provides direct access of antigens to the brain. Infectious hematopoietic necrosis virus (IHNV) is known to cause high mortalities in salmonids. The purpose of this study is to evaluate the safety of a live attenuated IHNV nasal (I.N) vaccine in rainbow trout (Oncorhynchus mykiss). In the olfactory organ, the vaccine was detected 1 and 4 days after primary I.N vaccination but not in the intramuscular (i.m) or control groups. In the brain, ...[more]
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