Ontology highlight
ABSTRACT:
SUBMITTER: Pacold ME
PROVIDER: S-EPMC4871733 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Nature chemical biology 20160425 6
Serine is both a proteinogenic amino acid and the source of one-carbon units essential for de novo purine and deoxythymidine synthesis. In the canonical pathway of glucose-derived serine synthesis, Homo sapiens phosphoglycerate dehydrogenase (PHGDH) catalyzes the first, rate-limiting step. Genetic loss of PHGDH is toxic toward PHGDH-overexpressing breast cancer cell lines even in the presence of exogenous serine. Here, we used a quantitative high-throughput screen to identify small-molecule PHGD ...[more]