Longitudinal persistence with secondary prevention therapies relative to patient risk after myocardial infarction.

ABSTRACT:

Background

Prior studies have demonstrated that patients with high-risk acute myocardial infarction (AMI) are less likely to receive guideline-directed medications during hospitalisation. It is unknown if this paradox persists following discharge. We aimed to assess if persistence with guideline-directed medications post discharge varies by patients' risk following AMI.

Methods

Data were analysed from two prospective, multicentre US AMI registries. The primary outcome was persistence with all prescribed guideline-directed medications (aspirin, β-blockers, statins, angiotensin-antagonists) at 1, 6 and 12 months post discharge. The association between risk and medication persistence post discharge was assessed using multivariable mixed-effect models.

Results

Among 6434

SUBMITTER: Shore S 

PROVIDER: S-EPMC4871817 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature