Ontology highlight
ABSTRACT:
SUBMITTER: Kawase R
PROVIDER: S-EPMC4871856 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Kawase Reiko R Nishimura Yuhei Y Ashikawa Yoshifumi Y Sasagawa Shota S Murakami Soichiro S Yuge Mizuki M Okabe Shiko S Kawaguchi Koki K Yamamoto Hiroshi H Moriyuki Kazumi K Yamane Shinsaku S Tsuruma Kazuhiro K Shimazawa Masamitsu M Hara Hideaki H Tanaka Toshio T
Frontiers in pharmacology 20160519
Exposure of rhodopsin to bright white light can induce photoreceptor cell damage and degeneration. However, a comprehensive understanding of the mechanisms underlying light-induced retinopathy remains elusive. In this study, we performed comparative transcriptome analysis of three rodent models of light-induced retinopathy, and we identified 37 genes that are dysregulated in all three models. Gene ontology analysis revealed that this gene set is significantly associated with a cytokine signaling ...[more]