Ontology highlight
ABSTRACT:
SUBMITTER: Chandran A
PROVIDER: S-EPMC4872120 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Chandran Anandhakumar A Syed Junetha J Taylor Rhys D RD Kashiwazaki Gengo G Sato Shinsuke S Hashiya Kaori K Bando Toshikazu T Sugiyama Hiroshi H
Nucleic acids research 20160420 9
Chemically engineered small molecules targeting specific genomic sequences play an important role in drug development research. Pyrrole-imidazole polyamides (PIPs) are a group of molecules that can bind to the DNA minor-groove and can be engineered to target specific sequences. Their biological effects rely primarily on their selective DNA binding. However, the binding mechanism of PIPs at the chromatinized genome level is poorly understood. Herein, we report a method using high-throughput seque ...[more]