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Liposome production by microfluidics: potential and limiting factors.

ABSTRACT: This paper provides an analysis of microfluidic techniques for the production of nanoscale lipid-based vesicular systems. In particular we focus on the key issues associated with the microfluidic production of liposomes. These include, but are not limited to, the role of lipid formulation, lipid concentration, residual amount of solvent, production method (including microchannel architecture), and drug loading in determining liposome characteristics. Furthermore, we propose microfluidic architectures for the mass production of liposomes with a view to potential industrial translation of this technology.

SUBMITTER: Carugo D

PROVIDER: S-EPMC4872163 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature

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Liposome production by microfluidics: potential and limiting factors.

Carugo Dario D Bottaro Elisabetta E Owen Joshua J Stride Eleanor E Nastruzzi Claudio C

Scientific reports 20160519

This paper provides an analysis of microfluidic techniques for the production of nanoscale lipid-based vesicular systems. In particular we focus on the key issues associated with the microfluidic production of liposomes. These include, but are not limited to, the role of lipid formulation, lipid concentration, residual amount of solvent, production method (including microchannel architecture), and drug loading in determining liposome characteristics. Furthermore, we propose microfluidic architec ...[more]

PMID: 27194474

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