Genetically diverse CC-founder mouse strains replicate the human influenza gene expression signature.
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ABSTRACT:
SUBMITTER: Elbahesh H
PROVIDER: S-EPMC4872221 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Publications
Genetically diverse CC-founder mouse strains replicate the human influenza gene expression signature.
Elbahesh Husni H Schughart Klaus K
Scientific reports 20160519
Influenza A viruses (IAV) are zoonotic pathogens that pose a major threat to human and animal health. Influenza virus disease severity is influenced by viral virulence factors as well as individual differences in host response. We analyzed gene expression changes in the blood of infected mice using a previously defined set of signature genes that was derived from changes in the blood transcriptome of IAV-infected human volunteers. We found that the human signature was reproduced well in the foun ...[more]
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