Acetaminophen hepatotoxicity and sterile inflammation: The mechanism of protection of Chlorogenic acid.
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ABSTRACT:
SUBMITTER: Jaeschke H
PROVIDER: S-EPMC4872296 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
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Acetaminophen hepatotoxicity and sterile inflammation: The mechanism of protection of Chlorogenic acid.
Chemico-biological interactions 20150910
Acetaminophen hepatotoxicity is characterized by extensive necrotic cell death and a sterile inflammatory response. A recent report suggested that a therapeutic intervention with chlorogenic acid, a dietary polyphenolic compound, protects against acetaminophen-induced liver injury by inhibiting the inflammatory injury. The purpose of this letter is to discuss a number of reasons why the protective mechanism of chlorogenic acid against acetaminophen hepatotoxicity does not involve an anti-inflamm ...[more]
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