Ontology highlight
ABSTRACT:
SUBMITTER: Miyamoto DT
PROVIDER: S-EPMC4872391 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Miyamoto David T DT Zheng Yu Y Wittner Ben S BS Lee Richard J RJ Zhu Huili H Broderick Katherine T KT Desai Rushil R Fox Douglas B DB Brannigan Brian W BW Trautwein Julie J Arora Kshitij S KS Desai Niyati N Dahl Douglas M DM Sequist Lecia V LV Smith Matthew R MR Kapur Ravi R Wu Chin-Lee CL Shioda Toshi T Ramaswamy Sridhar S Ting David T DT Toner Mehmet M Maheswaran Shyamala S Haber Daniel A DA
Science (New York, N.Y.) 20150901 6254
Prostate cancer is initially responsive to androgen deprivation, but the effectiveness of androgen receptor (AR) inhibitors in recurrent disease is variable. Biopsy of bone metastases is challenging; hence, sampling circulating tumor cells (CTCs) may reveal drug-resistance mechanisms. We established single-cell RNA-sequencing (RNA-Seq) profiles of 77 intact CTCs isolated from 13 patients (mean six CTCs per patient), by using microfluidic enrichment. Single CTCs from each individual display consi ...[more]