Species-conserved reconfigurations of brain network topology induced by ketamine.
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ABSTRACT:
SUBMITTER: Becker R
PROVIDER: S-EPMC4872411 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Publications
Species-conserved reconfigurations of brain network topology induced by ketamine.
Becker R R Braun U U Schwarz A J AJ Gass N N Schweiger J I JI Weber-Fahr W W Schenker E E Spedding M M Clemm von Hohenberg C C Risterucci C C Zang Z Z Grimm O O Tost H H Sartorius A A Meyer-Lindenberg A A
Translational psychiatry 20160419
Species-conserved (intermediate) phenotypes that can be quantified and compared across species offer important advantages for translational research and drug discovery. Here, we investigate the utility of network science methods to assess the pharmacological alterations of the large-scale architecture of brain networks in rats and humans. In a double-blind, placebo-controlled, cross-over study in humans and a placebo-controlled two-group study in rats, we demonstrate that the application of keta ...[more]
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